Designed for chronic migraine sufferers, it eliminates pill fatigue by combining the exact, clinically backed nutrients you need into one simplified routine.
3graine is effective because it delivers the exact daily doses neurologists recommend to target the underlying cellular and neurological mechanisms of migraines:
Magnesium (300mg): Up to 50% of migraine sufferers are deficient in magnesium. It actively regulates nerve signaling and supports healthy vascular tone.
Vitamin B2 / Riboflavin (400mg): Supports cellular energy production and helps lower oxidative stress, both of which are directly linked to migraine activity. Clinical trials show this specific daily dose can reduce migraine frequency by up to 50% within 3–4 months.
Coenzyme Q10 (200mg): Works alongside magnesium and B2 to help regulate nerve signaling and support normal neurological function.
The Adherence Solution: While neurologists frequently recommend these three supplements, patients historically struggle to see results because maintaining a routine of 8+ separate pills and multiple products a day is overwhelming. 3graine solves this by combining all three clinically-backed ingredients into one simplified daily dose of 3 capsules, making it possible to maintain the long-term consistency required for the nutrients to build up and compound in your system.
Ingredients
Medical Ingredients (per capsule):
Vitamin B2 (Riboflavin): 133.33mg (400mg per daily dose of 3 capsules)
Magnesium (Citrate): 100mg (300mg per daily dose of 3 capsules)
Coenzyme Q10 (CoQ10): 66.57mg (200mg per daily dose of 3 capsules)
Non-medical Ingredients:
Hypromellose
Magnesium Stearate
Microcrystalline Cellulose
How long until it works?
Weeks 1–3 Starting Phase: Your body is adapting. You may notice mild digestive changes or bright yellow urine (from B2, which is normal and typically resolves within ~2 weeks).
Months 1–2 Early Benefit: Some users begin to notice fewer migraine days and reduced severity. Stay consistent, even if changes are subtle, as prevention takes time.
Month 3+ Clinical Benefits: This is where results often become more noticeable, leading to a reduced frequency of migraines, less disruption to daily life, and improved overall consistency and control.
Shipping & Returns
Where do you ship? We ship nationwide within Canada and the United States. All online orders are shipped out of our facility in Ontario, Canada.
How long will it take to receive my order?
Processing time: Please allow 1-2 business days for orders to be processed.
Shipping times: 🇨🇦 Canada: Average of 2–6 days. 🇺🇸 United States: 4-10 business days.
How much does shipping cost?
Orders over $50: Free shipping within North America.
Orders under $50: $6 flat rate fee.
FAQ
Are there side effects? Some users may experience minor side effects in their first few weeks of taking 3graine, such as changes in urine color (due to B2) or mild digestive changes. These typically resolve after 1–3 months of consistent use.
When will I begin to see benefits? Most people who benefit will begin to see a response around 2-3 months of consistent use.
Do I need to take 3graine with food? We recommend taking 3graine with food to help reduce at any gastrointestinal side effects. Most people have found 3graine to be very tolerable with minimal side effects.
Designed for daily use, replenishing your body with essential nutrients to build systemic health over time.
Weeks 1-3
Initiation Phase
In this phase, your body is adapting, so if needed, you can start with one capsule daily and gradually work up to the full dose, during which you may notice mild digestive changes and bright yellow urine from the B2, which is perfectly normal.
Typically resolves within ~2 weeks.
Months 1-2
Early Benefit
You might notice fewer migraine days and reduced severity
Stay consistent, even if changes are subtle. Prevention takes time.
Months 2-3
Clinical Benefits
This is where results often become more noticeable, leading to a reduced frequency of migraines, less disruption to daily life, and improved overall consistency and control.
The compounding effect is kicking in.
Formulated using clinical experience.
Neurologists and health-care professionals routinely recommend patients to trial Magnesium, Riboflavin (B2), and CoQ10 for migraine prevention.
The Problem:
Three separate supplements
Multiple doses every day
A daily routine that's hard to maintain
But 3graine was developed to solve this.
It combines all three neurologist-recommended supplements into one single daily dose of 3 capsules.
Prevent and Reduce Migraine
Vitamin B2
400 mg
400mg daily shown in trials to reduce migraine frequency by up to 50% within 3–4 months
Supports cellular energy production and helps reduce oxidative stress both linked to migraine activity
Coenzyme Q10
200 mg
Clinical studies show benefits at 100–300mg daily with consistent use over 3+ months
Helps regulate nerve signaling and supports normal neurological function
Magnesium
300 mg
Supports neurotransmitters and vascular tone; up to 50% of migraine sufferers are deficient
Helps regulate nerve signaling and supports normal neurological function
Proud sponsor & partner of Migraine Canada®
A portion of every sale goes to support research & initiatives to helpimprove the lives of Canadians living with headaches and migraine.
Made in Canada
Authorized by Health Canada
Third-Party Tested
Meet the founder
Where clinical experience meets innovation.
Kevin Le is a Canadian-trained Physician Assistant dedicated to transforming patient care. He pioneered Rapid Access Headache Clinics, helped shape Ontario Health’s first virtual care policy for neurology, and developed specialized care models adopted by SickKids.
As the creator of 3graine—in partnership with Migraine Canada—Kevin is driven by a strong commitment to making healthcare simpler, more efficient, and fully accessible for every patient.
Frequently asked questions
How should I take 3graine?
The recommended dose is 3 capsules. If you are generally sensitive to supplements or medication you can start with one and increase to the full dose across a 2-3 weeks.
The capsules can be taken all at once or split throughout the day. The most important thing is that you are consistent with your routine.
Do I need to take 3graine with food?
Taking 3graine with food is a recommendation rather than it is a necessity.
Are there side effects?
As with many other supplements and medications, the supplements within 3graine can cause side effects. The most common being change in urine colour. Some other users may have gastrointestinal side effects. Based on the research, most users tolerate the supplements without any issues.
How long will one bottle last?
One month.
Has this product been tested/verified?
Yes! 3graine is third-party tested, and Authorized for Sale by Health Canada.
Is there a Moneyback Guarantee?
Migraine supplements take 2–3 months of consistent use before you may see benefits. To help you start the neurologist-recommended protocol with confidence, we offer a 30-day money-back guarantee on orders of 3 or more bottles. If you experience persistent side effects or have any tolerability concerns within the first 30 days, simply return your unopened bottles for a full refund. Return shipping costs are the responsibility of the customer.
Ship back any unopened bottles within 30 days of receiving your order. Contact us directly for the shipping address.
After 15 plus years of hormonal migraines I learned there is a vitamin supplementation recommended for this issue. 3Graine is the easiest way to get all 3 supplements in one easy pill. I’ve been taking them for 2+ months and feel that it’s helping along with occipital icing and electrolyte drinks prior to a migraine. I actually have hope. My last one lasted less than a day and I’m used to 3 day migraines twice per month. Couldn’t be more grateful!
S
Skye
reduces # tablets taken per day... some
For me, definitely helps reduce # of migraines occurring per month & lessens # of tablets taken per day... a bit. It's great that it's got B2, Mg, & Co-Enzyme Q10 all together, my only issue is the hospital's neuro team recommends doses of Vit B2 400mg, Mg 400mg, Co-Enzyme Q10 300mg for their patients. Thus, 3graine runs a bit short & I'm still having to supplement my supplements.
R
Rhonda Miller
Great product
The suppliments seem to help, and its much easier to take the triple formula in a single pill!
